What is Combivent used for?
Combivent generic is an aerosol medicine containing the active ingredients Salbutamol Sulfate and Ipratropium Bromide.
Combivent medication is odorless or odorless, available as an aerosol, and prescribed for the treatment of bronchial asthma and diffuse bronchial inflammation.
Pharmacokinetics
Combivent medication after administration is rapidly absorbed through the respiratory tract. Bioavailability is about 10%. The active substances do not penetrate the barrier between the blood system and the central nervous system. It does not enhance systemic absorption of the components, and therefore the pharmacological effect of Combivent generic is balanced in the lungs. Combivent generic acts within 8 hours and is excreted with urine after 24 hours.
Combivent: Indications
Combivent medication has a strong bronchodilator effect. With full efficiency, it prevents bronchial constriction, which may occur under the influence of external irritants such as cigarette smoke, cold air, stress, various allergens, nervousness.
The first active ingredient in Combivent Salbutamol sulfate has the properties of decreasing the tone and secretion of the bronchi and decreasing the tone of myomometry. After use, 10-20% of the substance reaches the lower respiratory tract, which is absorbed by the pulmonary tissue and penetrates into the pulmonary vessels without being metabolized. Reaches maximum plasma concentration within 2-4 hours. It is eliminated from the body mainly with urine and less with feces.
The second active substance of Combivent generic is Ipratropium bromide, which has anticholinergic effect and acts mainly on bronchial cholinoreceptors. It cures bronchospasm in obstructive bronchitis. When used nasally, it reduces nasal secretion of fluid in allergic and non-allergic runny nose. This substance is rapidly absorbed after inhalation and its bioavailability is less than 10% of the dose taken, while not penetrating the blood-brain barrier. It is excreted by the kidneys.
Combivent generic has a simultaneous local effect on muscarinic and beta-adrenergic receptors in the lungs, resulting in a stronger bronchodilator effect. At the same time, it does not increase systemic absorption.
Combivent: dosage
Combivent medication is administered by inhalation 2 doses 4 times a day. If necessary, the dose may be increased to 12 inhalations per day. The following steps should be taken when using the drug:
- Shake the can well.
- Take a deep inhalation.
- Hold the can upright with your mouth tightly against your lips.
- Inhale deeply while firmly pressing the spray bottle to release a single measured dose. Then hold your breath for a couple of seconds and take the can out of your mouth and exhale.
- The mouthpiece should be rinsed thoroughly after use.
Combivent: Side effects
- Headache
- Fainting
- Nervousness
- Tremors of the limbs
- Psychological agitation
- Dry mouth
- Decreased lower blood pressure and increased upper blood pressure
- Arrhythmia
- Nervous tic
- Allergic rash
Combivent: Contraindications
- Hypersensitivity to one of the active substances of the drug
- Tachyarrhythmia
- Hypertrophic cardiomyopathy
- Pregnancy in the first trimester
- Children under 12 years of age
- Take the drug with caution in case of:
- Closed glaucoma
- Obstruction of the urinary tract
- Severe cardiovascular disease
- Decompensated diabetes mellitus
- Cystic fibrosis
- Hyperthyroidism
- Pregnancy in the second and third trimester
- Breast-feeding
- Pheochromocytoma
- Previous myocardial infarction
- Special use
Special caution should be exercised when using the drug during pregnancy. The inhibitory effect of Combivent generic on uterine contractions must also be considered. One of the active substances of the drug may penetrate the breast milk of the mother, although the effect on the newborn has not been studied, it must be considered.
In some cases, eye complications such as eye pain, increased eye pressure, dilated pupils, red eyes, colored spots in front of the eyes, or the appearance of a halo may occur if the aerosol gets into the eyes. In such a case, it is necessary to begin treatment immediately with eye drops and call your doctor.
Patients with cystic fibrosis may be more prone to gastrointestinal motility disorders.
For the conditions listed above, Combivent medication may be prescribed only after balancing acceptable benefits against possible risks.
Systematic use of higher doses may worsen the course of the disease, so it is necessary to carry out regular monitoring of respiratory failure symptoms.
The use of Combivent medication for a long time may be inadvisable and even dangerous. Therefore, to prevent the worsening of the disease, which can be life-threatening, it is necessary to reconsider the plan of further treatment with this drug.
If acute, increasing dyspnea occurs or there is little efficacy with Combivent medication, a physician should be consulted.
Overdose
If you overdose on Combivent generic, the following symptoms may occur:
- Tachycardia
- Rapid breathing
- Heart palpitations
- Angina
- Arrhythmia
- Tremor
- Individual spots on different areas of the skin
In case of overdose, sedatives, tranquilizers are administered, and in more severe cases, intensive inpatient therapy.
Interaction with other medications
Concomitant administration of additional anticholinergic, diuretic and other agents may enhance the bronchodilator effect of the drug on the airways and cause side effects. There may be a significant reduction in the effect of the drug. Lead to a decrease in blood pressure. Increase the cardio tropic effect of thyroid hormones. Increase intraocular pressure. Likelihood of developing tachyarrhythmia. It may worsen the side effects of using anesthesia. Therefore, the drug should be discontinued at the time of surgery.
Rules of storage
Store the drug Combivent medication in a dry place, where it will not be exposed to strong heat, moisture or direct sunlight at temperatures not exceeding 25 °C. Restrict children's access to the drug.
Where can you order Combivent inhaler online?
You can purchase Combivent generic in our online pharmacy. Send the product to the cart and fill out the application form, provide your name and home address. We deliver Combivent generic to all cities in Mexico and the United States, at affordable prices.
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