Dilarmine Suspension Paramethasone Clhorpheniramine 100 ml

Dilarmine is an effective drug in veterinary medicine for the treatment of various allergic and inflammatory conditions in animals. This combination drug contains two active ingredients: Parametasone and Chlorpheniramine, which act synergistically to relieve symptoms and improve the animal's condition.

Parametasone belongs to the glucocorticoids class and plays a key role in suppressing inflammation and immune responses. This component works at the molecular level by acting on specific receptors within the animal's cells. After binding to these receptors, a complex is formed, which then moves into the cell nucleus and modulates the expression of various genes, including those responsible for the production of inflammatory mediators.

Chlorpheniramine refers to antihistamines that block histamine receptors. Histamine is one of the main mediators of allergic reactions, causing symptoms like itching, swelling and increased mucus production. By blocking, Chlorpheniramine prevents histamine from binding to its receptors, thereby reducing allergic manifestations and making it easier for animals to breathe.

The combination of these two substances in Dilarmine provides a comprehensive approach to the treatment of allergies and inflammation. Paramethasone effectively reduces inflammation and modulates the immune response, while Chlorpheniramine blocks allergic reactions at the molecular level. This results in a rapid reduction of symptoms and an improvement in the animal's overall condition.
 

Dilarmine what is it used for?
 

Allergic reactions: Dilarmine may be prescribed to treat allergic reactions caused by insect stings, food allergies, contact allergies, or medications. Symptoms of such reactions include itching, skin redness, swelling, and other manifestations.

Dermatologic diseases: The drug is effective in the treatment of dermatitis of various origins, including eczema and neurodermatitis. These diseases are often accompanied by severe itching, redness and inflammation of the skin.

Inflammatory diseases of the musculoskeletal system: Arthritis, bursitis and tendovaginitis can also be treated with Dilarmine due to its pronounced anti-inflammatory action.

Swelling: The suspension is used to reduce swelling associated with inflammatory processes or allergic reactions.
 

Dosage
 

The dosage of Dilarmine suspension should be strictly adhered to as recommended by the veterinarian, as it may vary depending on the species and weight of the animal, as well as the severity of the disease.

General recommendations: Typical dosage is 1 ml of suspension per 10 kg of body weight of the animal, once daily.

Duration of treatment: The suspension is usually administered once a day. The duration of the treatment course is from 3 to 7 days, but can be adjusted depending on the dynamics of improvement of the animal's condition.

Preparation for use: Before using the suspension, the vial should be shaken thoroughly to ensure homogeneity of the solution. This is critical to ensuring that the dosage of active ingredients is accurate.

Methods of administration: Dilarmine is administered to animals intramuscularly or subcutaneously. The choice of administration method depends on the condition of the animal and the veterinarian's recommendations.

Intramuscular injections: Provide rapid absorption and onset of action of the drug. This method is preferred when immediate relief of symptoms is needed.

Subcutaneous injections: May be preferred for home use, as they are less painful and easier to perform.

Supportive therapy

Potassium supplements: May be recommended for use with Dilarmine to prevent hypokalemia, especially if the animal is also receiving diuretics.

Calcium and Vitamins D: Long-term use of glucocorticoids may require supplementation of calcium and vitamin D in the diet to prevent osteoporosis.
 

Contraindications
 

Allergy to the drug components: If the animal is known to be hypersensitive to the components of Dilarmine suspension, use of the drug is strictly prohibited.

Pregnancy and lactation: The safety of Dilarmine use during pregnancy and lactation has not been established. Use during these periods is only possible after evaluation of the risk/benefit ratio by a veterinarian.

Viral Infections: The use of glucocorticoids in Dilarmine may aggravate the course of viral infections due to immunosuppressive effects.

Fungal and Bacterial Infections: Active fungal or bacterial infections may worsen under the influence of the drug, especially if they are not adequately treated.

Diabetes mellitus: The drug may increase blood glucose levels, making its use risky in diabetic animals.

Renal and hepatic insufficiency: Due to possible effects on metabolism and excretion, use in animals with impaired renal or hepatic function requires special caution.
 

Side effects
 

Increased thirst and increased urination: Dilarmine may cause these symptoms, especially with long-term use.

Changes in appetite: There may be both an increase and a decrease in appetite.

Gastrointestinal problems: Including vomiting and diarrhea. These symptoms may occur, especially if the dosage is not corrected.

Behavioral changes: Some animals may become more excitable or, conversely, apathetic.

Decreased immunity: Prolonged use may suppress the immune system, increasing the risk of infectious disease.

Muscle weakness and atrophy: Long-term use of the glucocorticoids in Dilarmine may lead to the development of these conditions.
 

Rapid onset and duration of the therapeutic effect
 

One of the important aspects when using Dilarmine is the speed of onset of the therapeutic effect. Due to the content of Paramethasone, which has a strong anti-inflammatory effect, the onset of action of the drug can be observed just a few hours after injection. This makes it an ideal choice for situations that require rapid intervention, such as acute allergic reactions or inflammatory processes.

The Chlorpheniramine in suspension Dilarmine also begins to take effect quickly, providing relief from allergy symptoms such as itching, redness, and swelling. The antihistamine properties of this ingredient help to control the release of histamine, resulting in the reduction of allergic manifestations in a short period of time.

The duration of the therapeutic effect of Dilarmine can vary depending on several factors, including dosage, method of administration, and the individual characteristics of the animal's body. In general, the effect of a single dose may last from 24 to 48 hours, after which repeated administration may be required to maintain the therapeutic effect.
 

Interaction with other medicinal products
 

Non-steroidal anti-inflammatory drugs: The combination of Dilarmine with NSAIDs may increase the risk of gastrointestinal ulcers and bleeding due to increased gastroerosive action of glucocorticoids and NSAIDs. This combination requires careful monitoring and may require dose adjustment of both drugs.

Diuretics: Dilarmine may aggravate electrolyte disturbances, especially hypokalemia caused by diuretics, which may require adjustment of the dose of diuretics or additional monitoring of potassium levels in the blood of the animal.

Insulin and diabetes medications: Parametasone may increase blood glucose levels, which requires dose adjustment of insulin or other hypoglycemic agents when co-administered with Dilarmine.

Anticoagulants: The glucocorticoid Parametasone may increase or decrease the effects of anticoagulants such as warfarin, which requires careful monitoring of coagulation parameters and possible dosage adjustment of anticoagulants.

Immunosuppressants: The combination of Dilarmine with other immunosuppressants may increase the suppressive effect on the immune system, which increases the risk of infections. This combination should be used under strict veterinary supervision.

Cytochrome P450 inhibitors: Certain drugs that affect liver enzymes may alter the metabolism of Paramethasone, affecting the efficacy and half-life of Dilarmine. Examples of such drugs include ketoconazole and itraconazole.
 

Dilarmine dosage forms: Purpose
 

Dilarmine Mexico is available in various dosage forms, allowing veterinarians to choose the best option depending on the specific needs and condition of the animal.

Dilarmine Suspension: The suspension provides rapid absorption of the active ingredients into the bloodstream, which is important when there is an acute need to treat inflammatory processes or allergic reactions. This form is ideal for emergency use when it is necessary to quickly achieve a high concentration of active ingredients in the blood of the animal.

Dilarmine Jarabe: Syrup for oral administration, convenient for regular use, especially when the animal is stressed or anxious from injections. Dilarmine jarabe is mainly used for long-term treatment of chronic conditions, as it makes it easier for animals to take the medication and allows for precise dosing of the active ingredient. May contain flavoring to improve palatability.

Dilarmine Pills: The tablet form of Dilarmine is designed for oral administration. Tablets are often used for regular treatment and maintenance of therapeutic effects for chronic conditions. Dilarmine tabletas are suitable for long-term treatment, allowing to ensure stable maintenance of the required level of drugs in the animal's body.