What is Lisinoprile used for? Lisinoprile para que sirve?

Lisinopril 10 mg is an ACE inhibitor that does not contain sulfhydryl. The tablets are intended for oral use. The mechanism of action of Lisinopril, as well as other angiotensin-converting enzyme inhibitors, is the stimulation of bradykinin cleavage and catalyzing the formation of Antiotensin II. 

Is Lisinopril a beta-blocker?

Lisinopril is not a beta-blocker. The drug effectively reduces total peripheral vascular resistance, which gives a hypotensive effect and allows for taking it as an adjunctive agent in renal and heart failure. In these pathologies, doses that have no significant effect on the reduction of blood pressure work.

How quickly Lisinopril 10 mg lowers blood pressure?

Absorption of Lisinopril is independent of food intake and varies between 25-60% (although some studies have shown individual variability starting at 6%). The drug reaches its maximum plasma concentration between 6-8 hours. Studies on animals have shown that Lisinopril 10 mg practically does not penetrate through the BBB.

The drug is excreted by the kidneys, unchanged. The half-life of Lisinopril is 12.6 hours. In clinically healthy patients the clearance is approximately 50 ml/min. 

The dosage of Lisinopril 10 mg allows it to be taken once daily. It is important to do this at approximately the same time interval. Start with the minimum therapeutic dose and gradually increase it to a steadily effective dose. Lisinopril can be used for a long time. 

Lisinopril is not only for monotherapy. It is also taken with other antihypertensive drugs. The tablets are present in many modern regimens. 

Lisinopril: dosage

At the beginning of treatment, some patients experience a rather sharp drop in BP. In such a case, it is possible to divide the minimum dosage of Lisinopril 10 mg in half or even into four parts. The same regimen applies if the patient has renal insufficiency.

The maintenance therapy dose is usually 2 tablets of Lisinopril 10 mg. If the therapeutic effect does not come within a month, the dose is increased. The safe daily maximum is 80 mg.  

The combination of Lisinopril with a diuretic may have an overly hypotensive effect; this should always be considered when taking it. Care should also be taken because of the risk of excretion of salt from the body, which can lead to a reduction in intercellular fluid volume. 

Lisinopril and alcohol

Lisinopril 10 mg is usually well tolerated. The incidence of various side effects is low. Increased side effects may be caused by the simultaneous use of alcohol, so you should be very careful when taking the pills.

Lisinopril: side effects

During studies, a significant effect of the drug on the kidneys was not established. Uremia was very rarely observed, even more rarely - anuria. People with renal disorders are recommended to monitor creatinine and urea levels, and with liver disorders - liver tests. 

Side effects have also been noted with Lisinopril such as:

• dizziness;
• anxiety;
• headache;
• impaired sense of taste;
• insomnia;
• orthostatic disorders.

Does Lisinopril cause erectile dysfunction?

Side effects of Lisinopril 10 mg in men related to libido and potency are extremely rare. In large-scale studies, the percentage of probability of irreversible impotence is zero.

Lisinopril: overdose

Lisinopril overdose has been described to a limited extent. Expectedly, an overdose may occur:

• acute hypotension;
• electrolyte imbalance;
• vascular insufficiency;
• tachycardia or bradycardia;
• dizziness;
• coughing;
• anxiety.

Saline solutions are mainly used for treatment by IV administration. Angiotensin or catecholamines may also be given. Lisinopril can also be excreted by hemodialysis, but this requires a strong indication.

Use of Lisinopril 10 mg during pregnancy

Medication is contraindicated in pregnant women or those who are planning a pregnancy. If pregnancy occurs, the drug should be discontinued and patients should be transferred to an active substance with lower risks.

Lisinopril cost

Lisinopril has an affordable price in our pharmacy, which may vary depending on the dosage. If you need further advice on the drug, contact our experts through our feedback form.