Lopid Gemfibrozilo generic 600 mg 28 tabs

600 mg
In stock
Package Size: 28 Tabs
Generic Name: gemfibrozilo
Substance: gemfibrozilo
Strength: 600 mg
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Lopid is an effective medicine designed to correct lipid metabolism. The active substance of the drug, gemfibrozil, helps to reduce the level of triglycerides and "bad" cholesterol (LDL) while increasing the level of "good" cholesterol (HDL) in the blood. This makes it an important tool in the fight against hyperlipidemia of various etiologies, including genetically determined forms. Lopid generic name of the main component of the drug - gemfibrozil, which is widely used in clinical practice to correct lipid disorders such as hypertriglyceridemia and hypercholesterolemia. This drug is particularly effective in situations where other treatment methods, including diet and physical activity, do not have sufficient effect.

Lopid indications

Hypertriglyceridemia: Lopid is used for significantly elevated triglyceride levels in the blood, which may contribute to pancreatitis and other cardiovascular diseases.

Mixed hyperlipidemias: In cases where the patient suffers from elevated cholesterol and triglyceride levels at the same time.

Hypercholesterolemia: Although gemfibrozil is not a first-line treatment for lowering LDL ("bad" cholesterol), it is used as an adjunct to other lipid-lowering therapies.

Prevention of cardiovascular disease: Especially in patients at risk of atherosclerosis due to dyslipidemia.

Mechanism of action: Lopid, the main active ingredient gemfibrozil, belongs to the class of fibrates, which modulate the activity of certain enzymes involved in lipid metabolism. Lopid medication is most commonly available in the form of 600 mg tablets and affects lipid metabolism in ways such as:

Activation of lipoprotein lipase: Lopid stimulates the production of this enzyme, which helps to break down triglycerides found in very low-density lipoproteins (VLDL) more efficiently. This lowers the level of triglycerides in the blood.

Decreased production of apolipoprotein C-III: The medication Lopid reduces the synthesis of this protein, which normally inhibits the action of lipoprotein lipase. Less apolipoprotein C-III increases the breakdown of triglycerides.

Increased production of apolipoprotein A-I: This improves the function of high-density lipoproteins (HDL), which help transport cholesterol from tissues back to the liver for utilization or excretion. This helps to increase levels of "good" cholesterol.

Lopid 600 provides significant benefits in the management of dyslipidemia and the prevention of related diseases, but its use should be strictly regulated by a physician.


Lopid tablets are used for the correction of lipid metabolism and have specific dosage recommendations depending on the disease and general condition of the patient. For adult patients, the standard starting and maintenance dosage of Lopid 600mg is one tablet in the morning and evening. This dosage of Lopid, provides optimal control of blood lipid levels and minimizes the risk of side effects.

Special Instructions

Renal insufficiency: If the patient has renal insufficiency, the dose of Lopid may be adjusted downward by the physician depending on the degree of renal dysfunction.

Elderly patients: In the elderly, the metabolism of the drug may be slowed, requiring dose adjustment or increasing the interval between doses.

Combination with other drugs: In concomitant administration with other drugs, especially statins, it is necessary to carefully monitor the patient's condition, as the combination may increase the risk of muscle disorders.

Contraindications to the use of Lopid

Liver Failure: Patients with active liver disease or persistently elevated liver function tests without a clear case should not take gemfibrozil.

Renal Failure: Patients with severe renal failure should avoid using this drug because of the risk of drug accumulation in the body, which may lead to toxicity.

Gallstone disease: Gemfibrozil may promote gallstone formation, so it is not recommended for patients with gallstone disease.

Hypersensitivity: Patients with known allergies to gemfibrozil or other components of the drug should not take it.

Lopid side effects

Side effects from taking Lopid can range from mild to serious and require attention from both patients and healthcare professionals.

  • Dyspepsia, nausea, and diarrhea: These symptoms are the most common and usually manageable.
  • Abdominal pain: May occur at the start of treatment and usually resolves on its own.
  • Myalgia, muscle weakness: In rare cases, Lopid may cause muscle pain or weakness, potentially progressing to rhabdomyolysis, especially when combined with other lipid-lowering drugs such as statins.
  • Increased liver enzyme levels: Increases in ALT and AST levels may occur, which usually normalizes after discontinuation of the drug.
  • Gallstone disease: As mentioned, gemfibrozil may contribute to the formation of gallstones.
  • Allergic Reactions: Skin rash, pruritic, angioedema, and other manifestations of hypersensitivity may require immediate discontinuation of the drug.
  • Fatigue and dizziness: These symptoms may occur and require consultation with a physician if they interfere with daily activity.


The drug known for its active ingredient gemfibrozil is a key medication for hyperlipidemia.  For example, gemfibrozilom itself is quite expensive, and its analog generic Lopid, which contains the same active ingredient and has the same therapeutic effect, is much cheaper. Lopid 600 mg price may vary depending on the number of tablets in the package and the country of sale. One example is generic Lopid in Mexico, where local manufacturers offer this drug at a significantly reduced price. For the convenience of patients living in different geographical areas, many pharmacy chains offer delivery services, which is especially important for those living in remote areas or those who prefer not to leave home.

Interaction of Lopid with other drugs


Risk of muscle disorders: The combination of Lopid with some statins, especially lovastatin, significantly increases the risk of myopathy and even rhabdomyolysis. If coadministration of this combination is necessary, the patient should be carefully monitored and a reduction in statin dosage should be considered.

Anticoagulants (e.g. warfarin)

Potentiating the effect of warfarin: Lopid may potentiate the effect of warfarin, increasing the risk of bleeding. Regular monitoring of blood clotting indices (INR) is necessary, and possibly an anticoagulant dose adjustment.

Hypoglycemic agents (e.g., insulin, oral antidiabetic drugs)

Increased hypoglycemic effect: Lopid may increase the effect of blood glucose-lowering agents, which requires dose adjustment of sugar-lowering drugs to prevent hypoglycemia.

Bilirubin and other drugs affecting the liver

Effect on metabolism: The drug may slow down the metabolism and increase the effect of drugs metabolized in the liver, which potentially increases their therapeutic and toxic effects.


Increased blood concentrations of cyclosporine: The main substance gemfibrozil, the drug Lopid, may increase levels of cyclosporine, which increases the risk of toxic reactions, including renal failure.

Colestyramine and other anion exchange resins

Decreased efficacy: Colestyramine may decrease the absorption of Lopid in the intestine, reducing its efficacy. An interval of several hours between taking these medications is recommended.

The medicine, Lopid 600mg, is a powerful tool in the treatment and prevention of diseases associated with disorders of lipid metabolism. However, its intake should be monitored by a medical specialist, especially in cases of chronic diseases or combined use with other drugs. Always follow your doctor's recommendations and monitor your body's reaction to the drug.

Package Size
28 Tabs
Generic Name
600 mg
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