Magnesium Valproate Generic 200mg 40 Tabs Extended Release

Magnesium-Valproate is a combination medicine also marketed under the brand name Valproato de Magnesio. The drug combines valproic acid, known for its anticonvulsant and mood-stabilizing effects, and magnesium, which plays an important role in maintaining normal functioning of the nervous system. This drug is often used to treat a variety of neurological and psychiatric conditions, including epilepsy, bipolar disorder, and migraines.

Mechanism of action

Valproate plays a key role in controlling neurochemical processes in the brain. It works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, which is a major inhibitory neurotransmitter. Increasing the concentration of GABA helps reduce nervous excitability, which leads to a decrease in the frequency and intensity of seizures and also stabilizes mood.

Magnesium enhances the protective effect of Valproate, since it itself helps to stabilize the electrical activity of neurons. Magnesium may also reduce the neurotoxic effects of Valproate, thereby reducing the risk of side effects.

Generic Magnesium-Valproate extended-release tablets provide gradual release of active components throughout the day, which has several advantages:

Improved symptom control: Consistent levels of medication in the blood help to better control symptoms, reducing the likelihood of sudden attacks or mood changes.

Reduced side effects: A more uniform dose distribution reduces the risk of side effects associated with peaks in drug concentrations in the blood.

Ease of administration: It is easier for patients to comply with the treatment regimen since they need to take pills less often.

Application

Magnesium-Valproate tablets may be prescribed for a variety of medical situations related to the nervous system and mental health. This drug, due to its properties, has a complex effect on the body. Let's consider in what specific cases these tablets can be prescribed.

Epilepsy: Magnesium-Valproate is often used to control seizures in patients with epilepsy. The drug helps stabilize electrical activity in the brain, which leads to a decrease in the frequency and intensity of attacks. It can be prescribed either as a primary medication or in combination with other antiepileptic drugs.

Bipolar Disorder: In cases of bipolar disorder, Valproate-Magnesium may be used to stabilize mood. This helps prevent or reduce extreme mood symptoms, such as manic or depressive episodes. The drug helps regulate mood and makes it more stable.

Migraine: The drug can also be prescribed for the prevention of migraines. The drug helps reduce the frequency and severity of migraine headaches. It is not used to treat headaches that have already started, but is used regularly to prevent new episodes.

Neuropathic pain: In some cases, doctors may consider Magnesium-Valproate as a treatment option for neuropathic pain—pain caused by nerve damage. Valproic acid may help reduce neuropathic pain through its effects on the nervous system.

Impulsive Behavior: Research has shown that Valproate-Magnesium may be effective in reducing impulsive behavior in people with various psychiatric disorders, including borderline personality disorder.

Dosage

The correct use and dosage is essential to ensure its effectiveness and minimize the risk of side effects. Below are general dosage recommendations for Valproate Magnesium 200 mg for various conditions. However, it is important to remember that only a doctor can determine the exact dosage based on the individual characteristics of the patient.

Epilepsy

For adults and children over 10 years of age, the starting dose is usually 15 to 20 mg per kilogram of body weight per day. This dose may be gradually increased depending on response to treatment and seizure control. The maximum daily dose should not exceed 60 mg per kilogram of weight.

Bipolar disorder

When treating bipolar disorder, the starting dose for adults can range from 750 mg to 2000 mg per day, divided into several doses. The dosage may be adjusted depending on the patient's response and the level of valproic acid in the blood.

Prevention of migraines

For the prevention of migraines, adults are usually prescribed 500 mg to 1500 mg of Valproate Magnesium per day in divided doses. It is important to start with a low dose and increase it gradually to minimize side effects.

General recommendations for admission

Valproate Magnesium 200mg may be taken with or after meals to reduce stomach irritation.

The drug should be taken at the same time every day to maintain a stable level of the drug in the blood.

A missed dose should be taken as soon as possible, but if it is nearing the next dose, do not double the dose to prevent overdosing.

Who is Valproate Magnesium contraindicated for?

Pregnant women: Valproate Magnesium is considered dangerous to use during pregnancy, especially in the first trimester, as it may cause birth defects in the baby. Doctors usually recommend that women of childbearing age use reliable contraception while taking this drug.

People with Liver Disease: Because Magnesium Valproate can have negative effects on the liver, people with pre-existing liver disease or reduced liver function are often contraindicated from using this drug.

People with porphyria: This is a rare metabolic disease in which Valproate Magnesium may worsen symptoms.

Children under 2 years of age: Age restrictions also apply due to the high risk of side effects and complications in this age group.

Patients with known hypersensitivity: If the patient has previously had an allergic reaction to any of the components of the drug, its use should be excluded.

Side effects

A variety of side effects may occur while taking Valproate Magnesium, and the severity may range from mild to severe:

• Nausea, vomiting, diarrhea and abdominal pain.
• Hepatic dysfunction.
• Dizziness, drowsiness, tremors, and sometimes more serious disorders such as impaired coordination of movements.
• Depression, aggression, and other mental changes.
• Increased risk of bleeding as Valproate Magnesium may affect blood clotting.
• Weight gain is one possible side effect, which may require adjustments to your diet and physical activity level.

Interaction of Magnesium Valproate with other drugs

Antiepileptic drugs: The drug may affect the blood levels of other antiepileptic drugs. For example, it may increase levels of phenobarbital and lamotrigine, which may require dosage adjustments of these medications under the supervision of a physician. However, other drugs, such as phenytoin, may affect the blood concentration of valproate, which may also require dosage adaptation.

Anticoagulants: Valproate Magnesium may enhance the effects of drugs such as warfarin, increasing the risk of bleeding. Patients taking both of these drugs should have their blood clotting levels checked regularly and the dose of the anticoagulant adjusted if necessary.

Aspirin: The combination of aspirin and Magnesium should be avoided, as it may increase the concentration of Valproate in the blood and increase the risk of side effects.

Antibiotics: Some antibiotics, such as erythromycin, may increase blood levels of valproate, which may require a dosage adjustment of Valproate Magnesium.

Antidepressants: Fluoxetine or Amitriptyline may affect the metabolism of Magnesium Valproate, changing its effectiveness and blood levels. This requires careful monitoring and possible dosage adjustments.

Contraceptives: Hormonal contraceptives may reduce the effectiveness of Valproate Magnesium, which is especially important for women being treated for epilepsy. Your doctor may recommend alternative methods of contraception or dosage adjustments.

As a result, we can conclude that Magnesium-Valproate 200 mg is an effective treatment for a number of neurological and psychiatric disorders. However, like any other drug, it requires careful use under strict medical supervision to maximize its benefits and minimize its risks.