Metformin Dabex XR 500 mg 30 Tabs

The prolonged-acting drug, produced under the trade name Dabex XR, is an effective and time-tested drug for the treatment of type 2 diabetes. Dabex with the active substance metformin, belongs to the class of biguanides, which have the property of reducing blood sugar levels. The drug not only helps to control blood sugar levels, but also helps to reduce the risk of complications. Dabex XR Metformina, thanks to its prolonged action, gradually releases the active substance, providing a longer therapeutic effect.

Para que sirve: Dabex XR 500 PLM

Principles of action

The work of Dabex 500 xr, thanks to its active ingredient, is aimed at:

• Reducing the production of glucose in the liver (gluconeogenesis).
• Increasing the sensitivity of tissues to insulin, which contributes to a more efficient use of glucose by body cells.
• Reduction of glucose absorption in the intestine, which prevents sugar spikes after meals.

The prolonged form of the drug (XR - extended release) provides a gradual and more even intake of metformin into the body during the day, which minimizes the risk of sharp fluctuations in blood sugar levels and reduces the likelihood of side effects from the gastrointestinal tract.
 

Indications
 

Dabex xr metformina 500 mg is prescribed for:

• Controlling blood glucose levels in patients with type 2 diabetes is difficult when dietary therapy and exercise alone are not sufficient.
• Used either as monotherapy or in combination with other sugar-lowering drugs such as insulin or sulfonyl urea derivatives.
• It can be prescribed to overweight patients, as metformin reduces the risk of cardiovascular disease and helps control body weight.
   

How to use and dosage
 

Dabex xr 500 mg tablets are taken orally once a day, preferably during dinner. The dose is selected by a doctor individually and can be increased to a maximum daily dose of 2000 mg depending on blood glucose levels and the tolerability of the drug. The initial dose is usually 500 mg per day, with a gradual increase after 1–2 weeks.

It is important to swallow the tablet whole, without chewing, so as not to disrupt the mechanism of gradual release of the active substance.
 

Contraindications
 

• Renal insufficiency or impaired renal function (CK below 30 ml/min).
• Acute or chronic heart failure or respiratory failure.
• Severe infections, dehydration, and sepsis.
• Acute alcohol intoxication or chronic alcoholism.
• Pregnancy and lactation period.
   

Side effects
 

• Gastrointestinal disorders: nausea, vomiting, diarrhea, abdominal pain, bloating. These symptoms occur more often at the beginning of treatment and pass over time.
• Metallic taste in the mouth.
• In rare cases, lactoacidosis, which is a serious complication and requires immediate medical attention. This condition may occur in patients with impaired kidney function or if the drug is used incorrectly.
   

Interaction
 

Dabex xr when taken concomitantly with other drugs, may affect their effectiveness and change their therapeutic effect. Therefore, it is necessary to carefully consider the combination of this drug with other drugs to avoid complications and side effects during treatment.
 

Antihyperglycemic drugs
 

• Insulin and its analogs: the combined use of Dabex XR with insulin increases the sugar-lowering effect, therefore, in this combination, it may be necessary to reduce the dose of insulin to prevent hypoglycemia.
• Sulfonylurea drugs (e.g., glibenclamide, gliclazide): increase insulin secretion, and in combination with metformin the risk of hypoglycemia increases. Therefore, the doses of these drugs may also be reduced.
• Thiazolidinediones: drugs such as pioglitazone increase tissue sensitivity to insulin and can be used safely with metformin. However, sugar levels need to be monitored to avoid hypoglycemia.
   

Antihypertensive agents
 

• Loop diuretics (e.g., furosemide): These drugs may increase the blood concentration of metformin, increasing the risk of side effects, especially lactoacidosis. The use of these diuretics requires careful monitoring of renal function.
• Antihypertensive drugs such as ACE inhibitors (enalapril, lisinopril) or angiotensin II receptor blockers (losartan) may increase the glucose-lowering effect of metformin, requiring glycemic control to prevent hypoglycemia.
   

Anticoagulants
 

• Warfarin: Metformin may increase the effect of anticoagulants, which increases the risk of bleeding. This interaction requires regular monitoring of blood clotting parameters to adjust the warfarin dosage if necessary.
   

Corticosteroids
 

• Corticosteroids (e.g., prednisolone) may increase blood sugar levels, which reduces the effectiveness of metformin. If prolonged steroid use is necessary, it may be necessary to adjust the dose of Dabex XR or increase glucose control to achieve normoglycemia.
   

Iodine-containing contrast agents
 

Iodine-containing contrast agents used for X-ray studies and computed tomography may cause renal dysfunction and increase the risk of lactoacidosis against the background of metformin intake. Therefore, when planning such studies, you should stop taking Dabex XR 48 hours before the procedure and resume it not earlier than 48 hours after the procedure, provided that kidney function is normal.
 

Antibiotics
 

• Ciprofloxacin and other fluoroquinolones: May both decrease and increase blood glucose levels when co-administered with metformin. This requires monitoring sugar levels and adjusting the dosage of the drugs.
   

Tetracyclines
 

• Their use may also increase the risk of lactoacidosis, so caution should be exercised.
   

Non-steroidal anti-inflammatory drugs
 

• Ibuprofen, diclofenac.
• Tenofovir.
• Cisplatin.
• Alcohol

Such drugs may affect kidney function, which increases the risk of accumulation of metformin in the body and increases the likelihood of lactoacidosis.

So, according to the above information, we can conclude that Dabex XR 500 tablets are an effective treatment for type 2 diabetes mellitus, providing long-term control of blood glucose levels. The prolonged form of the drug makes it convenient for patients, as taking the tablets once a day is enough. It is also important to strictly follow the doctor's recommendations and exercise caution in the presence of chronic diseases or taking other drugs to avoid negative consequences.