Dabex XR is a long-acting medicine used to control blood sugar levels in type 2 diabetes with the active substance Metformin. In addition to metformin, Dabex XR tablets contain auxiliary components that provide prolonged action of the medicine and help its absorption. These can be substances such as microcrystalline cellulose, hypromellose, and magnesium stearate. These components make Dabex more stable and ensure that the active ingredient is released slowly in the body, which helps to maintain the required level of metformin in the blood for a longer period.
How Dabex XR works
The mechanism of action of Dabex XR is quite complex, but let's try to explain its functions in simple words.
One of the main functions of Dabex Metformin is to reduce the amount of glucose that your liver releases into the blood. Normally, the liver produces glucose from so-called energy stores when blood sugar levels are too low. Metformin reduces this function, which helps lower your overall blood glucose levels.
Metformin helps your cells respond better to insulin. Insulin is a hormone that helps cells absorb glucose from the blood and use it for energy. When cells become more sensitive to insulin, they absorb glucose more efficiently, which also helps lower blood glucose levels.
Dabex XR can also slow down the rate at which glucose is absorbed from the digestive tract. This means that blood sugar levels rise more slowly after a meal, helping to prevent spikes in blood sugar levels.
Dabex para que sirve
Dabex XR tablets containing metformin are usually prescribed to treat certain conditions related to blood sugar levels. Here are the main cases where this drug may be recommended:
Type 2 diabetes mellitus
Dabex XR is most commonly used in patients with type 2 diabetes who are unable to control their blood sugar levels with diet and exercise alone. This medication helps to reduce the amount of glucose produced by the liver and improve the body's sensitivity to insulin.
Dosage: Usually, the starting dose of metformin is 500 mg once or twice a day. In the case of Dabex XR 750 mg, which is a prolonged-release form, your doctor may recommend starting with one tablet a day and then gradually increasing the dose depending on your body's response and blood sugar levels.
Polycystic ovary syndrome (PCOS)
Metformin is sometimes prescribed to treat PCOS, especially if the patient has insulin resistance, which is common with this condition. Metformin can help improve the menstrual cycle and lower insulin levels in the blood.
Dosage: Metformin dosage may vary in cases of CJD, but often starts with low doses with gradual increases to reduce the likelihood of side effects and to evaluate the drug's effectiveness.
Prediabetes
For prediabetic patients who have an increased risk of developing type 2 diabetes, metformin may be prescribed to reduce this risk. The drug helps manage glucose levels and may prevent or delay the development of diabetes.
Dosage: Doctors may prescribe metformin in low doses to prevent the development of type 2 diabetes. The recommended dose can often be the same as the initial treatment for diabetes, but you should always follow your doctor's instructions.
Weight maintenance
Metformin may also be recommended for some patients to help with weight control, especially those who suffer from obesity and related metabolic disorders.
Dosage: Typically, when metformin is used for weight maintenance, doctors start with a low dose of 500 mg per day to assess the tolerability of the drug and its effect on the patient's body. If the drug is well tolerated, the dosage can be gradually increased. The maximum recommended dose of metformin is usually 2000–2500 mg per day, spread over several doses. However, for Dabex XR, which has prolonged action, the dose can be adjusted by a doctor depending on individual needs.
Who is contraindicated with Dabex XR 750
There are several conditions and factors in which the drug is contraindicated:
Kidney failure: Metformin is excreted from the body by the kidneys, and if kidney function is impaired, there is an increased risk of the drug accumulating in the body, which can lead to serious complications.
Severe liver conditions: Because the liver plays a key role in the management of glucose and lactate, liver dysfunction may be exacerbated when taking metformin.
Acute heart failure: If heart failure requires treatment with medications that retain fluid in the body, it may not be safe to use metformin.
Acute infectious diseases, dehydration: Conditions that may affect kidney function may increase the risks associated with taking metformin.
Follow-up period after surgery: It is recommended to temporarily discontinue metformin after surgery due to the risk of developing renal failure.
Alcoholism: Chronic alcohol consumption increases the risk of lactate acidosis when taking metformin.
Side Effects
Various side effects may occur while taking Dabex XR 750, some of which may require medical intervention:
Gastrointestinal Disorders: The most common side effects include nausea, vomiting, diarrhea, abdominal bloating, and loss of appetite. These symptoms are most common at the beginning of treatment and may decrease over time.
Metallic taste in the mouth: Some patients may experience a change in taste sensation.
Lactate acidosis: This is a rare but serious complication that can be fatal. Symptoms include fatigue, weakness, muscle aches, breathing problems, unusually cold skin, dizziness, and slow heart rate.
Hypoglycemia: Although metformin by itself rarely causes low blood sugar, the risk increases if the drug is taken in combination with other antidiabetic medications.
Interaction with other drugs and substances
Alcohol: Interaction of metformin with alcohol may increase the risk of lactate acidosis, a potentially dangerous condition caused by the accumulation of lactic acid in the blood.
Iodine-containing contrast agents: When x-ray studies are performed using iodine-containing contrast agents, such as angiography or CT scans, metformin may increase the risk of kidney failure. It is generally recommended to stop taking metformin 48 hours before and after these procedures.
Diuretics: Some diuretics, especially loop diuretics, may increase the effect of metformin on blood glucose levels and increase the risk of hypoglycemia. They may also affect kidney function, which is important to consider when using metformin.
ACE inhibitors and angiotensin II receptor blockers: These drugs used to treat high blood pressure may affect kidney function, which requires caution when using them concomitantly with metformin.
Insulin and other diabetes medications: Metformin is often prescribed in combination with other medications to control blood glucose levels. Careful monitoring of the patient's condition is necessary, as the combination may increase both the effectiveness of treatment and the risk of hypoglycemia.
Antibiotics: Some antibiotics, such as ciprofloxacin, may interact with metformin, increasing its concentration in the blood, which requires adjustment of metformin dosage.
Drugs affecting the gastrointestinal tract: Drugs affecting the motility of the gastrointestinal tract may alter the absorption of metformin, which requires dose adjustment.
Forms of release
In addition to Dabex XR, the drug may be available in the form of Dabex Plus. This is a combination drug, also intended for the treatment of type 2 diabetes, but unlike Dabex, it combines two active ingredients: metformin and another active ingredient, often gliclazide, which improves the effectiveness of metformin in controlling blood glucose levels. Metformin, as already described, helps reduce glucose production in the liver, increases tissue sensitivity to insulin, and slows glucose absorption in the intestine. Gliclazide stimulates the pancreas to produce more insulin. This increase in insulin levels helps lower blood glucose levels after meals, providing more stable sugar levels throughout the day.
Warning!
We would like to note that this article is written for informational purposes, so Dabex XR 750 plm should be used strictly as prescribed by a doctor, who will choose the dosage based on the patient's individual needs and his response to treatment. This will help you use the drug effectively, avoid adverse reactions, and not harm your health.
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