Prednisone 20mg is a glucocorticosteroid that has a wide spectrum of action. It has a complex effect on the body and has anti-inflammatory, anti-allergic, desensitizing, antishock, and immunosuppressive effects.
Prednisone medication stabilizes cell membranes, decreases the accumulation of macrophages, and reduces leukocyte passage. Under the action of the drug, capillaries become less sensitive to infiltration, which leads to a decrease in edema. Prednisone tablets act on the mediators that cause inflammation, reduces the activity of lymphocytes.
The maximum concentration in blood is reached in 1.5 hours. The elimination half-life is on average 2 hours. Near 20% of the substances formed during metabolism are excreted from the body unchanged.
Prednisone medication is prescribed in a dosage of 20-30 mg/day. Then there is a gradual transition to a lower dosage of 5-10 mg. For the treatment of particularly acute conditions, it is possible to increase the dose to 100 mg for 24 hours. After the condition improves, a gradual transition to a 5-15 mg maintenance dose is possible. In children, the drug is prescribed in a dose of 1-2 mg/kg. The dose is divided into 5-6 admission within 24 hours. Prednisone tablets are taken with plenty of clean water, without chewing. If you cancel the treatment, you should gradually reduce the amount of the drug.
Indications for use of Prednisone medication
The drug has proven effective in the treatment of:
- Systemic pathologies of connective tissue
- Rheumatic disorders, inflammation of joints of varying severity
- Renal insufficiency
- Allergic diseases
- Hepatitis
- Gastrointestinal diseases
- Blood diseases
- Autoimmune pathologies
- Eye diseases of various etiologies
The glucocorticosteroid hormone can be used to treat several dozen diseases of different body systems. Most often, doctors prescribe it with other drugs.
Prednisone for cough
Prednisone 5 mg is used during the complex therapy of bronchial asthma and cosmetic status. The drug is also effective for the treatment of various diseases of the respiratory system. It can be used in acute alveolar, fibrosis, tumors, pneumonia, and tuberculosis. Treatment with the drug is carried out with other means necessary to eliminate the symptoms and the cause of their appearance.
Prednisone and alcohol
During treatment with the drug, it is necessary to refrain from drinking alcohol because of the high risk of an allergic reaction. Alcohol not only has a negative effect on the body but also reduces the effectiveness of the treatment.
Prednisone: contraindications
Prednisone tablets should not be used if the patient has an individual intolerance to glucocorticosteroids. The drug is contraindicated if the patient has recently had an infection of viral, bacterial, or parasitic origin. Do not take Prednisone tablets after vaccination for up to 12 weeks. Contraindications also include immune system disorders and HIV.
The drug is contraindicated in the pathology of the cardiovascular system, recent myocardial infarction, high blood pressure, and heart failure. Prednisolone is not used to treat patients with type 2 diabetes mellitus. Contraindications include impaired kidney function. Other contraindications are a history of osteoporosis, severe obesity, hypoalbuminemia, and glaucoma.
Prednisone: interactions
Prednisone medication with thyroid hormones may decrease its effects. Increased action and toxicity are possible with concomitant use with estrogens, and antibiotics of cyclosporine series. Antacids reduce the absorption of the drug. The risk of gastrointestinal deterioration occurs when concomitant use of the drug with non-steroidal anti-inflammatory drugs and salicylates. Taking the drug simultaneously with cardiac glycosides increases their toxicity and may cause arrhythmias. Reduces the effectiveness of drugs used to treat blood pressure. May increase intraocular pressure.
The drug is not used with antidepressants because of the risk of increased depression. Combined with contraceptives may cause hirsutism and acne. Prolonged treatment increases the amount of folic acid in the body and decreases the absorption of vitamin D and calcium. It is better not to use it with antiemetics, fluoroquinolones, anticholinesterase drugs, muscle relaxants, somatotropin, and adrenal cortex inhibitors.
Because of the wide impact on the body and numerous various restrictions in combinations, only a doctor should prescribe the drug. Before the start of treatment, it is necessary to carry out a comprehensive study of all organs and perform a detailed blood test. It is also necessary to monitor the condition after the start of treatment with Prednisone 5mg and react to any changes in time to avoid the development of adverse reactions.
Prednisone: weight gain
Infrequent adverse reactions include an increase in appetite, which can lead to weight gain, but this effect occurs rarely. Prednisolone may cause gastrointestinal disturbances.
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