Benadryl Generic, 120ml (Difenhidramina)

250 mg
In stock
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Benadryl Generic 120ml, containing the active ingredient Difenhidramina, is a widely used and reliable remedy to relieve the symptoms of allergies and other conditions. In Mexico, this drug is known by the trade name Brudifen, which highlights its popularity and acceptance in the pharmaceutical market.

What is Benadryl

Benadryl is an antihistamine medication that is used to relieve allergy symptoms such as itching, runny nose, sneezing, and allergic reactions to insect stings. Diphenhydramine is also effective in treating cold symptoms and can be used as a sedative.

Benadryl (Difenhidramina) Uses

Benadryl is used to relieve allergic reactions of various origins, to treat runny noses and coughs caused by colds, and to relieve redness, itching, and swelling associated with allergies. The drug can also be used for the short-term treatment of insomnia due to its sedative effect.

How long does Difenhidramina syrup work?

The effect of taking Difenhidramina syrup occurs within 15–30 minutes after use and may last from 4 to 6 hours. The time of action may vary depending on the individual characteristics of the patient's body.

Dosage of Benadryl (Difenhidramina) syrup

The dosage of Benadryl Syrup should be strictly according to the doctor's instructions or the instructions on the package. The usual dosage for adults and children over 12 years of age is 25–50 mg every 4–6 hours, not exceeding the maximum daily dose.


The use of Benadryl (diphenhydramine) may not be recommended in the following cases:

  • Allergy to diphenhydramine: You should not take Benadryl if you have a known allergy to diphenhydramine or to any of the drug's excipients.
  • Angle glaucoma: Diphenhydramine may increase intraocular pressure, which is dangerous for people with angle glaucoma.
  • Difficulty urinating: Patients with prostate disease or other conditions that cause difficulty urinating should avoid Benadryl because of its anticholinergic effects.
  • Chronic Respiratory Diseases: Patients with chronic bronchitis, asthma, and other respiratory diseases should use caution because of the potential for worsening symptoms.
  • Pregnancy and lactation: The use of Benadryl during pregnancy and lactation should be done only under the prescription of a physician, as diphenhydramine may penetrate the placental barrier and into breast milk.

Side Effects

Benadryl can cause a number of side effects, the intensity of which can range from mild to more serious:

  • Drowsiness and fatigue: One of the most common side effects of diphenhydramine is marked sedation, resulting in drowsiness and fatigue, which may impair the ability to drive and perform potentially hazardous tasks.
  • Dry mouth: Diphenhydramine has anticholinergic properties that may cause dry mouth, throat and nose.
  • Dizziness and coordination problems: Some patients may experience dizziness and coordination problems after taking Benadryl.
  • GI disorders: Nausea, vomiting, constipation, or diarrhea may also occur as side effects of diphenhydramine.
  • Vision disorders: Temporary blurred vision or difficulty with accommodation are also possible side effects due to the anticholinergic action of diphenhydramine. 6. Changes in emotional state: In some cases, moods of agitation or, conversely, depression may be observed, especially in children and the elderly.
  • Tachycardia: In some patients, diphenhydramine may cause palpitations.

Urinary disorders: In rare cases, Benadryl may provoke difficult or painful urination.

Interaction with other medicines

Diphenhydramine may interact with a number of other drugs, which may enhance or weaken their effect, as well as increase the likelihood of side effects:

  • Alcohol and sedatives: Increased sedation, which may result in significant central nervous system depression.
  • Antidepressants and antipsychotics: Increased risk of anticholinergic side effects and increased CNS depression.
  • MAO inhibitors: May increase and prolong the anticholinergic and sedative effects of diphenhydramine.
  • Antiasthmatic drugs: May increase anticholinergic side effects.


Before starting Benadryl, it is important to discuss all possible contraindications and side effects with your doctor, especially if you are already taking other medications or have a chronic medical condition. If any serious side effects occur, you should stop taking the drug immediately and seek medical attention. You should also avoid driving vehicles or performing potentially dangerous tasks until it becomes clear how the drug affects your ability to concentrate and react.

How much Benadryl (Difenhidramina) is in the body, and what are the routes of excretion?

Diphenhydramine is metabolized in the liver and excreted mainly by the kidneys. The elimination half-life of diphenhydramine ranges from 4 to 8 hours in healthy adults, but this time may be prolonged in patients with impaired liver or kidney function. Complete excretion of the drug from the body may take up to 24 hours after the last dose.

Benadryl in Mexico

In Mexico, Benadryl and its generics, such as Brudifen, are widely available in pharmacies and are used to treat the same conditions as in other countries. Acquisition and use of Benadryl in Mexico should follow the same precautions as in other regions, with particular attention to dosage, side effects, and interactions with other medications.

Benadryl Generic, containing diphenhydramine, is an effective treatment for allergy symptoms and temporary relief from cold symptoms. However, like any medical drug, it requires careful use with consideration of dosage, possible side effects, and interactions with other medications. Before starting Benadryl or its generics, such as Brudifen, it is important to consult your doctor, especially if you have a chronic medical condition or are taking other medications.

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