Pariet, is a powerful drug used to treat a wide range of gastrointestinal disorders. The drug is used to treat a variety of gastrointestinal disorders such as peptic ulcer disease, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. Its main action is aimed at reducing the amount of acid produced by the stomach.
The active substance of the drug, rabeprazole, is a proton pump inhibitor. It blocks specific proteins in the stomach wall that are responsible for acid production. This has the effect of reducing the acidity of gastric juice and improving the symptoms associated with excessive acidity.
After taking Pariet tablets, the active ingredient rabeprazole begins to work in the stomach, inhibiting proton pumps and reducing acid production. This process can take several hours, but the results become noticeable within an hour of ingestion. However, it may take a long time to achieve the full therapeutic effect, especially in the treatment of peptic ulcers or gastroesophageal reflux disease.
The dosage of Pariet tablets depends on the specific disease, its severity, and the individual characteristics of the patient. Pariet 20mg is the standard dosage of this drug, which contains the active ingredient rabeprazole, which is a proton pump inhibitor.
Here are some general dosage recommendations for Pariet 20 mg tablets for various medical conditions:
Peptic Ulcer and Gastroesophageal Reflux Disease (GERD) : It is generally recommended to take one Pariet 20mg tablet once a day, usually in the morning before meals. The duration of treatment is determined by the doctor and depends on the severity of the diseases and the rate of healing.
Zollinger-Ellison syndrome: Patients with Zollinger-Ellison syndrome may be prescribed a higher dosage of the drug depending on the degree of gastric juice hypersecretion. Usually the initial dose is 20 mg twice a day, but sometimes it may be necessary to increase it to 40 mg twice a day under medical supervision.
The first and most obvious contraindication is a known allergic reaction to rabeprazole or other ingredients of the drug. Patients who are allergic to the drug or any of its ingredients should avoid using it, as it can lead to serious allergic reactions, including anaphylaxis.
Pregnant women should also be cautious when using the Pariet drug. Although there is no direct evidence of harmful effects on the developing fetus, there is always a risk to pregnancy and the health of the baby. Therefore, the use of the Pariet drug during pregnancy should be strictly monitored.
Contraindications to the use of Pariet also include conditions such as severe liver failure. Since Pariet medicine is metabolized in the liver, people with severe liver dysfunction should use this medicine with caution or avoid using it completely.
Another important contraindication is the condition of children under 12 years of age, as the safety and efficacy of Pariet drugs in this age group have not been established.
In addition, patients with hypersensitivity to other proton pump inhibitors may also be at risk of hypersensitivity reactions when using Pariet tablets.
Headache: One of the most common side effects of Pariet medication is headache. This can manifest as mild discomfort or more severe pain that can affect daily activities.
Diarrhea or constipation: Some patients may experience changes in bowel transit while using Pariet. This may manifest as diarrhea or, conversely, constipation.
Nausea: Some people may experience nausea or even vomiting as a result of taking Pariet tablets, especially at the beginning of treatment or when the dosage is changed.
Fatigue: Fatigue or weakness is another possible side effect of the medication. Some patients may feel fatigued or tiredness, especially at the beginning of treatment.
Decreased appetite: Some patients may experience a decrease in appetite while using the medication. This may lead to a decrease in the amount of food consumed and eventually weight loss.
Allergic reactions: Although rare, some people may experience allergic reactions to Pariet, manifested as a skin rash, itching, facial swelling, or difficulty breathing. If such symptoms occur, you should immediately stop taking the drug and consult a doctor.
Effect on the liver: In rare patients, Pariet 20 mg may affect liver function, which may manifest itself in increased levels of liver enzymes in the blood. Therefore, it is recommended to regularly monitor liver function during treatment.
Antibiotics: Pariet may interact with some antibiotics, especially those used to treat Helicobacter pylori infections, such as amoxicillin and clarithromycin. Co-administration may increase the blood concentrations of these antibiotics, which may increase the risk of adverse effects or toxicity.
Cardiovascular drugs: Pariet may interact with some drugs for the treatment of cardiovascular diseases, such as cardioselective beta-adrenoblockers (e.g., metoprolol), as well as with drugs that increase the level of potassium in the blood (e.g., spironolactone). This may increase the concentration of these drugs in the blood and increase the risk of side effects such as decreased blood pressure or heart rhythm disturbances.
Osteoporosis drugs: Using Parieta medicine together with bisphosphonates, such as alendronate or risedronate, may reduce their effectiveness because it reduces the acidity of stomach juice, making it difficult for them to be absorbed properly.
Drugs metabolized in the liver: Pariet drugs are metabolized in the liver through the cytochrome P450 system; combined use with other drugs metabolized by this system may lead to an increase or decrease in their concentration in the blood.
Drugs affecting the pH of gastric contents: Pariet may interact with drugs that alter the pH of gastric contents, such as antacids or drugs containing alginates. Co-use may affect the effectiveness of Pariet or other medicines.
Drugs that increase the level of magnesium in the blood: Co-use of Pariet tablets with drugs such as digoxin or diuretics may increase the risk of hypermagnesemia (high levels of magnesium in the blood).
The effects of Parieta usually last for a long time, allowing patients to get stable relief from symptoms when used properly.
The duration of the drug's effects can last up to 24 hours after a single dose. This allows patients to take the drug once a day, which provides convenience and increases treatment adherence.
The half-life of Pariet, that is, the time during which the concentration of the drug in the blood is reduced by half, is approximately 1–2 hours. This means that after each dose, half of the active ingredient, rabeprazole, is eliminated from the body during this time.
However, despite the short half-life, the duration of action of Pariet is due to its mechanism of action and binding to proton pumps in the stomach. This process provides a gradual and stable decrease in the acidity of gastric juice for a long time after taking the drug.
At our pharmacy, you can buy Pariet online without worrying about its authenticity and efficacy. We ensure that the drug offered by us is authentic and of high quality. We also provide a free consultation on the use of the drug so that you can be sure to use it properly and get maximum benefits from the treatment.
We also have a convenient delivery system that allows you to receive your order in the shortest possible time from the comfort of your home. We value your time and care about your comfort, so we try to make the purchase process as convenient for you as possible.
In addition to Pariet, we have a wide range of other medical products, vitamins and nutritional supplements. We strive to provide you with everything you need to maintain your health and well-being.
Do not doubt the quality of our products and services. Contact us, and we will be happy to help you with your medical needs.
It can be said that Pariet-Rabeprazole is an effective and widely used drug for treating various gastrointestinal disorders. However, its use should be under the supervision of a doctor, as recommended, to minimize the risk of side effects and maximize the therapeutic effect.