Neomycin may also cause severe muscle relaxation progressing to paralysis and breathing problems. This possibility increases if you are also taking anesthetics, neuromuscular-blocking agents (eg, succinylcholine), or if you are receiving massive transfusions of citrate anticoagulated blood. Use with other aminoglycosides (eg, paromomycin) or other nephrotoxic/neurotoxic medicines (eg, bacitracin), advanced age, and dehydration all increase the risk of side effects. Potent diuretics (eg, ethacrynic acid, furosemide) should also be avoided because they can cause hearing loss.
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