Macrodantin is a medicine whose main active ingredient is Nitrofurantoin. The drug is classified as an antibiotic and is mainly used for the treatment and prevention of urinary tract infections (UTIs). There is also a generic version of Macrodantin- Macrofurin on the market that has identical therapeutic actions.
The drug belongs to a group of antibiotics known as nitrofurans, which belong to the class of antibacterial drugs. The action of Macrodantin is aimed at inhibiting key biochemical processes in bacterial cells, which leads to their death. Generic Macrodantin is effective against a wide range of bacteria that cause urinary tract infections.
Macrodantin used for the treatment of acute and chronic infections such as cystitis and urethritis. It is widely used in urology against most strains of bacteria.
The active ingredient, Nitrofurantoin, works by killing bacteria in the urinary tract. Once it enters the body, it is quickly converted into an active form that attacks proteins and other vital structures of the bacteria, rendering them unable to reproduce and survive. It is important to note that Macrodantin is only effective in the urinary tract, and its concentration remains low in other organs.
Macrodantin indication
Acute urinary tract infections: Macrodantin tablets are often prescribed for cystitis caused by bacteria. This condition is accompanied by frequent and painful urination and heaviness in the lower abdomen.
Chronic infections: In some cases where urinary tract infections become chronic or difficult to cure due to bacterial resistance to other antibiotics, Macrodantin can be used as an alternative remedy.
Prevention of infections: The drug can also be prescribed to prevent recurrent urinary tract infections, especially in people who suffer from frequent inflammation. In such cases, the drug is taken in lower doses for a longer period of time to prevent new infections.
Treatment after medical procedures: Doctors may recommend taking Macrodantin after certain medical procedures that may increase the risk of developing urinary tract infections, such as catheter placement or urinary tract surgery. The drug is used to reduce the chance of bacterial infections after such interventions.
Macrodantin dosage
Treatment of acute urinary tract infections: To treat acute infections such as acute cystitis, it is usually recommended to take one 100 mg Macrodantin capsule 4 times a day. The course of treatment may take 5 to 7 days, depending on the severity of the condition.
Prevention of recurrent urinary tract infections: Taking 50–100 mg once daily at bedtime may be recommended to prevent recurrent infections. This prophylactic therapy may be continued for several months or even longer, based on medical conditions and individual susceptibility to infections.
Treatment of chronic urinary tract infections: For chronic infections, it is recommended to take Macrodantin 100mg every 6 hours, but the course of treatment will be extended to 10–14 days or longer, depending on the response to treatment.
Duration of treatment: It is important to fully complete the course of treatment, even if symptoms have disappeared, in order to completely destroy the bacteria and avoid the development of antibiotic resistance.
Contraindications
Patients with severe renal dysfunction: Nitrofurantoin requires normal kidney function for effective removal from the body. If renal function is reduced, the drug may accumulate in the body, increasing the risk of toxicity.
Pregnant women, especially late-term mothers: Use of Macrodantin in the last weeks of pregnancy may affect fetal development.
Women who are breast-feeding if the baby is less than one month old: Nitrofurantoin may pass into breast milk and may be harmful to newborns.
People with severe liver dysfunction: Since the drug is metabolized in the liver, taking it may aggravate existing liver disease.
People with certain hereditary diseases: If you have glucose-6-phosphate dehydrogenase deficiency, you should not take Macrodantin as it may increase the risk of hemolytic anemia.
People who are allergic to the components of the drug.
Side effects
- Nausea, vomiting, diarrhea.
- Headache and dizziness.
- Rash and itching.
- Change in the color of urine.
- Coughing, difficulty breathing, and chest pain.
- Increased liver enzymes, jaundice.
- Numbness, tingling, or pain in your extremities.
Interaction of Macrodantin with other drugs
Antimicrobial drugs: Chloramphenicol, ciprofloxacin and norfloxacin may reduce the antimicrobial effect of nitrofurantoin. Using these drugs along with Macrodantin may reduce its effectiveness in fighting infections.
Drugs that reduce acid secretion in the kidneys: Probenecid and sulfinpyrazone, may slow the excretion of nitrofurantoin from the body, which increases its concentration and may lead to increased toxicity.
Drugs that alter urine pH: Antacids containing magnesium tricylate may decrease the absorption of nitrofurantoin, reducing its effectiveness.
Gout medications: Colchicine, allopurinol and other gout medications may affect the excretion of nitrofurantoin, which may also require dosage adjustments.
Diabetic drugs: Sulfonylureas used to treat diabetes in combination with nitrofurantoin may increase the risk of developing low blood sugar.
Thiaminosalicylic acid: May decrease the absorption and effectiveness of nitrofurantoin, which requires close monitoring by a physician.
Where do I purchase Macrodantin?
For starters, Macrodantin is most often sold with a doctor's prescription, as it is an antibiotic with specific indications for use. However, in some countries and under certain conditions, it can be purchased without a prescription.
Buying Macrodantin online provides a convenient option, especially if you are looking for better deals on price. Many online pharmacies offer competitive prices and the convenience of shipping directly to your door. That said, it is important to choose trusted and licensed online pharmacies to avoid counterfeits and ensure the quality of the drug you purchase.
The price of Macrodantin can vary depending on where you buy it. Usually, online pharmacies have lower prices than fixed pharmacy outlets due to lower operating costs. The cost may also depend on the dosage and the number of pills in the package.
One interesting option is to buy Macrodantin from Mexican online pharmacies. Mexico is known for offering medications at more affordable prices than many other countries, and many pharmacies have international shipping options. Plus, in some cases, you can buy medications without a prescription in Mexico, making the buying process faster and easier.
According to the above information, we can say that generic Macrodantin is an effective antibiotic to fight bacterial infections of the urinary tract, but its use requires strict adherence to the prescription. Be sure to discuss possible side effects and contraindications with your doctor before you start taking it. It is always important to remember the full course of treatment, even if the symptoms have disappeared earlier.
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