Micardis is a medicine designed to control high blood pressure. Micardis Duo, is a combination medicine with two active ingredients: 80 mg of Telmisartan and 10 mg of Amlodipine, as well as auxiliary ingredients that ensure the correct form, stability and absorption of the drug. Let's take a closer look at the composition of these tablets and their purpose.
Active ingredients
- Telmisartan is an angiotensin II receptor blocker. This means that it blocks the action of certain chemicals in the body that can cause narrowing of blood vessels. Thanks to this substance, blood vessels dilate, which leads to a decrease in blood pressure.
- Amlodipine belongs to a class of drugs known as calcium channel blockers. It helps to relax the walls of blood vessels, which also helps to reduce pressure in the arteries.
Auxiliary ingredients
- Microcrystalline cellulose - used to give volume to the tablets.
- Pregelatinized starch - serves as a binder to help hold the shape of the tablet.
- Magnesium stearate - acts as a binder to facilitate tablet production.
- Silicon Dioxide - Provides moisture resistance and prevents the ingredients from sticking together.
In these cases Micardis Duo tablets may be prescribed
Uncontrolled hypertension
Micardis Duo is often prescribed to patients whose blood pressure cannot be controlled with a single medication. If treatment with one drug is not effective, adding a second component may improve results. Telmisartan and Amlodipine in Micardis 80/10 act synergistically, enhancing each other's effects and providing stronger and more sustained blood pressure reduction.
High risk of cardiovascular complications
In patients at high risk of cardiovascular disease, such as coronary heart disease or previous heart attacks, where blood pressure control is important. In these cases, the medication helps to effectively manage blood pressure, thereby reducing the risk of serious complications like myocardial infarction or stroke.
Presence of multiple risk factors
For people who suffer from multiple risk factors at the same time, such as diabetes, obesity, or high cholesterol, combination medications like Micardis may be prescribed for a comprehensive approach to reduce the risks of cardiovascular disease.
Patients with individual intolerance or side effects
If patients experience side effects from one of the components (e.g., coughing from ACE inhibitors), the physician may switch them to Micardis, which may be more tolerable and effective in controlling blood pressure.
A desire to simplify the medication regimen
Sometimes doctors suggest switching to Micardis Duo to simplify the medication regimen. Instead of taking two separate pills, patients can take one pill, making it easier to adhere to their medication regimen and improving compliance with medical recommendations.
Dosage
Hypertension
In most cases, the starting dose is 40/5 mg once daily. However, to achieve a more significant reduction in blood pressure, the doctor may prescribe the drug at a dosage of Micardis 80/10 mg once a day, which is optimal for most patients.
Increased risk of cardiovascular diseases
Patients at high risk for cardiovascular disease are often prescribed 1 tablet of Micardis 80/10 daily. This dose helps control blood pressure and protects the heart and arteries from damage.
Chronic kidney failure
In cases of chronic kidney failure, the dosage may be adjusted by your doctor depending on the degree of kidney dysfunction. Usually start with a lower dose and increase it cautiously, depending on the body's response and kidney function parameters.
Elderly patients
Elderly patients are often prescribed a standard starting dose of 40/5 mg, as this group may have hypersensitivity to the medication. The physician may increase the dose to 80 mg/10 Micardis per day if the drug is well tolerated and effectively controls blood pressure.
Contraindications
Allergy to components: If the patient is allergic to telmisartan, amlodipine or other components of the drug, its administration is strictly prohibited.
Pregnancy: Micardis Duo is contraindicated in pregnant women, especially in the second and third trimesters, because the active components may adversely affect the development of the fetus.
Liver disorders: Patients with severe liver dysfunction should avoid taking this drug, as it may aggravate their condition.
Pediatric age: The drug is not recommended for use in children and adolescents due to the lack of data on safety and efficacy.
Side effects
- Headache, dizziness, fatigue.
- Swelling, especially in the ankles or legs, caused by amlodipine.
- Palpitation (sensation of rapid heartbeat).
- Blood pressure fluctuations, including a possible feeling of fainting when standing up.
- Nausea, diarrhea, or constipation.
- Rash, itching, swelling of the face, lips, tongue, or throat, which may make it hard to breathe.
- Increased potassium levels in the blood, which can lead to serious heart problems.
- Kidney failure, especially in patients with pre-existing risks.
Interaction of Micardis Duo with other medicines
Diuretics: Combining Micardis Duo with diuretics may result in an additional decrease in blood pressure. This can be both beneficial and risky if the decrease in blood pressure is too great.
Beta-blockers and ACE inhibitors: The combination of these drugs with Micardis Duo may also increase the hypotensive effect, requiring careful medical monitoring.
Potassium-saving diuretics, potassium supplements, potassium-containing salt substitutes: These drugs may increase the level of potassium in the blood, which is dangerous to the heart. Telmisartan, which is part of Micardis Duo, may also increase potassium, which increases the risk.
CYP3A4 inhibitors: Amlodipine is metabolized by the CYP3A4 enzyme. Drugs that inhibit this enzyme, such as grapefruit juice, certain antibiotics, and antifungal agents, may increase the blood concentration of amlodipine, which increases its effects and side effects.
Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen and naproxen: These drugs may decrease the effectiveness of Micardis Duo and increase the risk of kidney failure in some patients.
Lithium: Drugs containing lithium may interact with telmisartan, increasing the risk of lithium toxicity. Close monitoring of blood lithium levels is required when combining these drugs.
Diabetes medications: Telmisartan may increase insulin sensitivity, which requires adjustment of the dose of sugar-lowering drugs.
Where can I buy Micardis DUO?
Micardis DUO is a popular treatment for high blood pressure that can be purchased in a variety of forms, including brand names and generic versions.
Buying Micardis online is a convenient option that allows you to compare prices at different pharmacies. Mexican online pharmacies often offer competitive prices for this drug, and many of them even provide the option to order Micardis without a prescription. The price of Micardis can vary depending on where you buy it and the form of the drug. Generic Micardis is usually offered at a lower price than the original Micardis DUO, making it an affordable choice for many patients. However, before placing an order, it is important to make sure that the online pharmacy is reliable and legitimate. Check other customers' reviews and the pharmacy's licensing information.
Micardis DUO vs. Micardis Plus: What are the differences?
Micardis DUO and Micardis Plus are two medications designed to treat high blood pressure that fall under the category of antihypertensives. Both of these medications contain telmisartan as the main active ingredient, but they have some key differences related to the second active ingredient and the area of use.
Micardis Plus combines telmisartan and hydrochlorothiazide. Telmisartan is an angiotensin II receptor blocker that helps relax blood vessels, thereby lowering blood pressure. Hydrochlorothiazide is a diuretic that helps remove excess water and salts from the body, while also helping to lower blood pressure. This medication is most often prescribed when monotherapy with Telmisartan or other medications is ineffective. The addition of hydrochlorothiazide enhances the antihypertensive action, making Micardis plus an effective choice for more complex cases of hypertension.
Micardis DUO includes telmisartan and amlodipine. Amlodipine is a calcium channel blocker that also helps reduce tension in blood vessels and improve blood flow. This combination may be prescribed when a milder, but stable, reduction in blood pressure is needed. Amlodipine combines well with Telmisartan because both components act synergistically but by different mechanisms, allowing for effective blood pressure control without significant fluctuations.
It should be emphasized that the content of this article is for guidance only. The use of Micardis DUO should occur only as prescribed by the attending physician, who will determine the proper dosage based on the unique needs and treatment response of each patient. This approach will maximize the effectiveness of the drug, minimize the risk of side effects, and prevent possible harm to health.
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